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The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

"In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.

Antihistamines are commonly used to treat the symptoms of allergies and reactions to bites and stings.

Histamine is released as a reaction to foreign substances (allergens), and starts a chain reaction that leads to the release of other chemicals that add to the allergic response. There are two different types of antihistamine; sedating antihistamines, which can enter the brain and cause drowsiness and non-sedating antihistamines which do not.

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to produce the early swelling, redness and heat of an inflammatory response.

The same mediators may sensitize nerve endings to other pain-producing mediators such as bradykinin.

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Histamine is stored in Antihistamines are medications that counteract the effect of the natural chemical histamine.